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Breast, Mammography, Comparative studies, Cancer, Neoplasia
E. Lopez Uzquiza1, S. Sánchez Bernal2, A. Lamagrande Obregón2, E. Torres Diez2, A. Vega Bolivar2, P. Merino Rasillo2; 1Suances/ES, 2Santander/ES
Aims and objectives
The goal of a mammography screening program is to identify breast cancers in an early stage,
prior to their dissemination.
Although mammography has been shown to be a very useful screening method for the detection of breast cancer,
there remains a group of tumors detected in the interval between screening examinations,
called interval cancers (IC).
There are at least three types of problems that lead to failure of detection by mammography: 1) Technical or interpretive errors,
2) Characteristics of the breast or tumor (increased mammographic breast density,
an absence of microscopic and mammographic calcification,
etc…) and 3) Some subset of cancers not detected by mammography appears to be rapidly growing during the screening interval.
Published studies show that IC and screen-detected tumors have different clinicopathological characteristics,
IC being more aggressive.
IC tends to have a worse prognosis,
with a higher proportion of large tumors,
lymph node involvement,
high histologic grade and negative hormone receptors.
interval-detected cancers constitute a heterogeneous group of tumors that must be evaluated with respect to clinical presentation and tumor characteristics to explain the relative contribution of these features to the efficacy of mammographic screening.
Our purpose is to retrospectively compare the tumor size and lymph node status between the interval and screened detected cancers diagnosed during the last three rounds (2007-2012) in the screening program in Cantabria.