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Keywords:
Multidisciplinary cancer care, Cancer, Comparative studies, MR-Spectroscopy, Oncology, Breast, Pathology
Authors:
S. Makkat1, A. Schiettecatte1, Y. Fierens2, K. De Pierre1, M. Carprieaux1, J. De Greve1, M. Vanhoey1, J. de Mey1; 1Brussels/BE, 2Jette/BE
DOI:
10.1594/ecr2015/C-2179
Results
Among the 23 patients,
11 were grade II and 12 were grade III tumors.
Ki67 could not be assessed in one grade III sample as it had extensive necrotic tissue.
Strongly elevated tCho with a maximum concentration up to 2.53 mmol/kg was measured in grade III tumors.
Figure 1 illustrates an example of a low Ki67 expressed malignant breast tumor where the HER-2 gene is amplified and has a tCho of 1.134 mmol/kg measured from the choline peak of the spectra
There was a general correlation between Ki67 index and the tCho,
significant only in Grade III tumors (r=0.83,
p<0.05) (Figure 2).
There is a linear correlation between tCho and tumor grades (r=0.54,
p value <0.05).
Mean tCho values were significantly different between Grade II and III tumors (t test,
p value = 0.05) (Figure 3).
At the same time,
in grade II tumors,
by taking the mean tCho (0.22 mmol/kg) as the cut-off value,
a rough delineation could be observed: a group of tumors (n=8) with absent or very low(< 0.2mmol/kg) tCho and another group with a detectable tCho (n=3).
These three cases with detectable tCho were HER2 amplified.