Our statistical analysis showed a slightly increased association,
which was not significant between Factor V Leiden,
RPL and thrombotic placental damage.
Analysis RPL subgroups revealed an association between FVL and first trimester loss.
Due to the limitations of the available data,
the analysis on factor V Leiden incorporates both homozygous and heterozygous carriers.
These women were found to be at higher risk of pregnancy loss in the second compared with the first trimester (OR 5.0; 95% CI 2.2-8.9 and 2.0; 95% CI 1.02-03.80,
respectively).
11,12,13
There was a significant association between the combination of FVL and MTHRF (two polymorphisms) and placental adverse outcomes (thrombotic placental damage) analyzed by abnormal placental texture gray-scale ultrasound and blood flow resistance uterine and umbilical arteries Doppler.
Thrombophilia as associated with an increased risk of placenta abruption,
but significant associations were only observed with heterozygous factor V Leiden (OR 4.80; 95% CI1.15- 19.62) and heterozygous prothrombin (OR 7.80; 95% CI 3.03-19.79).14,15
There was a significant association between prothrombin and early pregnancy loss (OR 2.5; 95% CI 1.25-5.00).
There was a significant association between the combination of protein S and C deficiency16,17 and placental adverse outcomes (thrombotic placental damage),
showed high blood flow resistance in the uterine and umbilical arteries,
assessed by multigate Doppler examinations.
Acquired activated protein C resistance was associated with a higher risk of recurrent pregnancy loss in the first trimester (OR 2.70; 95% CI 1.25-5.63) than non-recurrent loss.18,19,20
Acquired activated protein C resistance and the combination of FVL and MTHRF shown a high systolic to diastolic ratio (S/D) in umbilical arteries.10,21
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