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Type:
Educational Exhibit
Keywords:
Lymphoma, Imaging sequences, MR-Spectroscopy, MR, CT, Oncology, Neuroradiology brain, CNS
Authors:
A. Brakus, K. Petrovic, N. Vuckovic, S. Stojanovic, J. Ostojic; Novi Sad/RS
DOI:
10.1594/ecr2015/C-2577
Background
Primary central nervous system lymphoma (PCNSL) is a form of extranodal lymphoma defined as isolated involvement of the craniospinal axis in the absence of primary tumor elsewhere in the body.
PCNSLS aretypically involving the brain,
less often the leptomeninges,
eyes and spinal cord.
These rare aggressive neoplasms of the brain represent about 3 percent of all primary brain tumors [1]; their incidence is significantly higher in the immunocompromised patients then in general population.
Long-term immunosuppression in transplant patients,
AIDS and autoimmune disease are conditions associated with increased risk of primary CNS lymphomas.
Clinical presentation is variable and depends on localization and the immune status of the patient: more than half of patients have non-focal,
non-specific symptoms like altered mental status,
symptoms of increased intracranial pressure and/or generalized seizures.
Focal neurologic deficit or partial seizures are uncommon,
but possible symptoms.