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Keywords:
CNS, Neuroradiology brain, Vascular, MR, MR-Diffusion/Perfusion, Diagnostic procedure, Ischaemia / Infarction, Haemorrhage
Authors:
E. Gangemi1, A. Charidimou2, D. Werring2, H. R. Jäger2; 1Rome/IT, 2London/UK
DOI:
10.1594/ecr2016/B-0823
Methods and materials
MRI scans of 65 patients seen at the National Hospital for Neurology and Neurosurgery,
Queen Square (London), between April 2005 and April 2014,
with a diagnosis of probable CAA,
according to the modified Boston criteria,
and cSS,
were retrospectively analysed.
All images were examined by a radiology resident (E.G.),
blinded to
clinical information,
who analyzed all the scans available for each patient,
starting from the diagnosis and including all the follow up scans. Acute/subacute small ischaemic lesions (ASIL) were identified as small cortical/subcortical hyperintense foci (<5mm) on DWI sequences and with corresponding dark areas on apparent diffusion coefficient (ADC) maps by E.G.; uncertain cases were reviewed by a senior vascular neuroradiologist (R.J.) to reach consensus,
blinded to other imaging sequences and clinical details.
The onset of ASIL (at the diagnosis or during the follow up) and the location of ASIL were reported,
taking into account the distribution of coexisting intracerebral haemorrhages,
cerebral microbleeds and cSS.