This poster is published under an
open license. Please read the
disclaimer for further details.
Keywords:
Neuroradiology brain, MR-Functional imaging, Localisation, Geriatrics
Authors:
O. Omelchenko, Z. Rozhkova, I. Karaban; Kyiv/UA
DOI:
10.1594/ecr2016/B-1338
Methods and materials
Group of 30 right-handed PD patients (12F,
46-74 y.o.) was studied by fMRI with 1.5T SIGNA (GE,
USA).
According to the UPDRS tremor severity and sidedness,
it was divided into four subgroups.
Left side tremor: GLlignt (7 patients,
2F,
tremor 0-1),
GLsevere (11 patients,
5F,
tremor 2-4).
Right side tremor: GRlignt (6 patients,
3F,
tremor 0-1),
GRsevere (6 patients,
1F,
tremor 2-4).
Total brain activation was analysed for GLlignt,
GLsevere,
GRlignt,
GRsevere.
Right-hand finger tapping task was used for fMRI activation.
Also,
brain activation during the audio-motor transformation phase (AMT,
onset of voice command of movement start/stop) and movement execution phase (solely) was analyzed for age-matched healthy volunteers (Gr1),
left (Gr2) and right (Gr3) lateralized tremor PD patients (taken and combined from the previously described groups with medium tremor severity).
Gr1 consisted of 7 healthy subjects (4F,
51-83 y.o.).
Gr2 consisted of 6 non-demented (MoCA 25-27,
tremor 1-3) PD patients with left-side (non-primary hand) tremor (2F,
53-74 y.o.).
Gr3 consisted of 5 non-demented (MoCA 25-30,
tremor 1-3) PD patients with right-side (primary hand) tremor (2F,
56-74 y.o.).
Simple reaction time in Gr1/Gr2/Gr3=302/352/328 ms.
Single shot GE-EPI sequence was used for BOLD imaging (TR/TE=3000/71 ms,
voxel size=4x4x5 mm).
Anatomical images were acquired with FSPGR sequence (TR/TE=11.6/5.2 ms,
TI=450 ms,
voxel size=1x1x1.5 mm).
FMRI data processing was carried out using GLM (FEAT) and ICA (MELODIC) based software from FSL (Oxford,
GB).
Pre-processing,
including motion correction,
slice timing correction,
spatial smoothing (FWHM=8 mm) was done.
Single subject and group GLM and ICA analyses were done.