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Keywords:
Neuroradiology brain, MR-Functional imaging, Localisation, Geriatrics
Authors:
O. Omelchenko, Z. Rozhkova, I. Karaban; Kyiv/UA
DOI:
10.1594/ecr2016/B-1338
Purpose
Parkinson's disease (PD) typically manifests with unilateral motor signs and subsequently evolves a number of motor and non-motor symptoms [Hoehn and Yahnr,
2001].
Resting tremor is one of the main Parkinson’s disease (PD) symptoms.
Tremor asymmetry is considered a crucial criterion for PD and may influence hemisphere-associated cognitive functions [Erro et al.
2012].
It is still debated whether the lateralization of PD symptoms influences the way of future disease progression,
especially concerning non-motor symptoms development and the role of DMN in this process [Erro et al.
2012,
Riederer and Sian-Huelsmann.
2012.].
PD is associated with abnormal hypersynchronicity in basal ganglia-thalamocortical loops [Baudrexel,
2011].
Subthalamic nucleus (STN) gained increased attention in PD due to its role in deep brain stimulation for PD symptoms treatment.
STN was shown to be activated during the movement execution [Rodrigues-Oroz,
2001].
Also,
bilateral activation and synchronization of left and right STN upon or prior to the hand movement onset and until the end of movement was shown for left and right unilateral hand movement [Darvas,
2014].
STN was shown to participate in movement error detection [Tan,
2014] and to function as a central component of an arbitrary system of the basal ganglia [Servestani,
2011].
Different effects of DBS of left/right/bilateral STN in PD was shown,
comprising speech worsening in left STN DBS,
while no such effect in right or bilateral STN DBS,
supposing laterality dependent STN functioning [Schulz,
2012].
Nevertheless altered pattern of brain activation in tremor/no-tremor PD patients was shown,
no tremor laterality and severity patients’ subdivision was previously done.
We propose the analysis of brain activation in PD patients with different tremor laterality and severity for evaluation of PD-subtype specific fMRI response.