This poster is published under an
open license. Please read the
disclaimer for further details.
Keywords:
Neuroradiology brain, MR-Functional imaging, Localisation, Geriatrics
Authors:
O. Omelchenko, Z. Rozhkova, I. Karaban; Kyiv/UA
DOI:
10.1594/ecr2016/B-1338
Results
fMRI data showed the common pattern of brain activation for all studied subjects: bilateral primary (M1S1),
premotor,
supplementary motor cortex,
thalamus and cerebellum Fig. 1 .
Increase of activation volume(voxels)/ΔBOLD (%) amplitude was shown in (GRlight>GRsevere>GLsevere>GLlight): (3736/2.22,
3281/1.96,
1664/1.36,
1274/1.33) respectively Fig. 2.
Activation of the subthalamic region was shown in GRlight,
GRsevere during the movement execution.
Decrease of M1S1 activation was shown in GRsevere Fig. 1.
Bilateral cortex activation in PD patients under unilateral motor task execution is explained by plasticity changes in brain motor network.
Activation of the subthalamic region in severe tremor patients might have the compensative physiological background.
Decreased activation of M1S1 in GRsevere reveals the decrease of excitatory input in M1S1.
Also,
the brain activation during AMT was analyzed.
We hypothesized that AMT plays the important role in voice-guided movements’ initiation and STN involvement,
especially in lateralized PD.
GLM and ICA-based analyses of AMT for Gr1,
Gr2,
Gr3 revealed activation of neural network consisted of the bilateral posterior temporal lobe,
precuneus,
supplementary motor area and cingulate motor region Fig. 3.
Left STN activation during AMT was shown for Gr1,
Gr2,
Gr3 Fig. 4.
Bilateral activation of STN for G2 during AMT was shown.
Specifically,
bilateral activation of STN during the movement phase (additional to the left STN activation during the AMT) was shown for G3 Fig. 5.
Increased total volume of activation was shown for G3 in comparison to G2 Fig. 6 .
The process of voice-guided movement execution and AMT in PD patients and age-matched subjects evokes activation of several neural networks.
Auditory cortex,
SMN and pC participate in AMT,
which was previously shown [Warren et al.
2005].
PD symptoms laterality have no impact onto the AMT neural network activation while it has an important impact onto the STN functioning.
Left STN was shown to have more importance for AMT.
Bilateral STN activation in left sided PD symptoms suppose the idea that specifically left STN play important role in PD symptoms,
while right STN activates only in case of left PD symptoms prevalence.
While STN was shown to correlate with tremor laterality and occurrence [Helmich,
2012],
it was shown that STN participate in movement error correction [Servestani,
2011].
Specific activation of bilateral STN during the movement execution in primary side affected PD patients,
together with increased total volume of activation and quite shorter simple reaction time suppose STN compensative and corrective role in movement.