The Aim of This Study To investigate the significance of descriptors of malignant NME in breast MRIs in assessing presence of invasion or lymph node metastasis. Introduction Non-mass enhancement (NME) observed in magnetic resonance imaging (MRI) of breasts is often associated with in situ lesions (1-3). However, NMEs with invasive components reportedly account for 10–42% of total malignant NMEs (1, 2, 4). In situ and invasive lesions should be managed differently, especially when recent controversy about overtreatment of in situ breast cancer is taken into...

Subjects Total 139 malignant NMEs; Between January 2008 and December 2009 Initially interpreted by one radiologist (13 years of experience in breast imaging and had read approximately 8,000 breast MRI examinations before January 2008) at the time of clinical care, unblinded to patients’ clinical information and imaging findings (mammography and breast ultrasound examinations). Excluded 4 cases: axillary lymph node metastasis was suspected clinically and primary axillary lymph node dissections were performed without preceding sentinel lymph node biopsies. 4 cases: MR studies were performed for recurrent...

Study Subjects and Lesions 131 malignant NMEs, age 31-73 years (mean 43.5 years). 76 in situ lesions and 55 invasive breast cancers. Axillary lymph node metastasis (ALNM) positive 13 out of 55 with invasive breast cancers. The widest dimension of NMEs: 6–96 mm (mean: 41.8 mm). In situ: 6–92 mm (mean: 39.9 mm) vs invasive lesions: 9–96 mm (mean: 44.3mm) (P = 0.25), Invasive lesions with ALNM: 19–61 mm (mean: 40.4 mm) vs without ALNM: 9–96 mm, (mean: 45.5 mm) (P = 0.48). Analysis between...

Despite the modest interobserver agreement, dichotomous assessment of IEPs turned out to be valuable for estimating the presence of invasive components within malignant NMEs. If assessed dichotomously, the presence of clustered rings, hypointense area IEPs, and heterogeneous structures, assessed collectively, indicates invasive components for malignant NMEs. Discussions Pathology of malignant NMEs Previous studies have shown that the most common pathology of malignant lesions seen as NME was ductal carcinoma in situ (DCIS) (1, 2). However, as implied by our study, 42% (55/131) had invasive components...

This poster shares substantial amount of study details, tables and figures, with our article which is under consideration for publication by Academic Radiology as of December 11th 2015, under the title of "Descriptors of malignant non-mass enhancement of breast MRI: their correlation to the presence of invasion".

1. Liberman L, Morris EA, Lee MJ, et al. Breast lesions detected on MR imaging: features and positive predictive value. AJR American journal of roentgenology. 2002; 179(1):171-8. 2. Jansen SA, Shimauchi A, Zak L, Fan X, Karczmar GS, Newstead GM. The diverse pathology and kinetics of mass, nonmass, and focus enhancement on MR imaging of the breast. Journal of magnetic resonance imaging : JMRI. 2011; 33(6):1382-9. 3. Jiang L, Zhou Y, Wang Z, Lu X, Chen M, Zhou C. Is there different correlation with prognostic...