Depletion of skeletal muscle mass (sarcopenia) and obesity influence cancer patients' outcome and increase anticancer drug toxicity. The purpose of this study was to evaluate the effect of body composition measured by CT volumetry on liver hypertrophy after portal vein embolization prior to major liver resection.

Native CT scans of seventy six patients with liver malignancies (25 female, 51 male) were evaluated. 27 HCC 8 IH-CCC 41 colorectal metastasis Muscle volumes at L3 vertebra were measured using manual contouring and Hounsfield unit thresholds (-30 to +150) Muscle volume less than 39 cm2/m2 (female) and 55 cm2/m2 (male) was considered as sarcopenia [1]. Patients with BMI over 25kg/m2 were considered as overweight or obese [2]. Estimated future liver remnant (FLR) was measured with CT-volumetry.

Among the 25 female patients 12% had sarcopenia, 24% had normal weight, 76% were obese or overweight, these results at the male patients were: 49%, 23,5%, 76,5%. Patients with sarcopenia had significantly lower FLR increment after PVE than patients without sarcopenia (24.19 ± 21.36% vs. 53.1 ± 34.47%, p=0.0056). Patients with normal BMI and sarcopenia had significantly lower FLR increment after PVE than patients with normal BMI without sarcopenia (21.06 ± 26.19% vs. 80.17 ± 43.96%, p<0.01). Patients with obesity and sarcopenia had significantly lower...

Patients with sarcopenia have impaired liver regeneration. Assessment of body composition before portal vein embolization is therefore important and, if need be, nutritional correction should be made.

Ibolyka Dudás, M.D. Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary [email protected] Zsuzsa Straky, M.D. Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary Éva Török, 1st Department of Surgery, Semmelweis University, Budapest, Hungary Péter Pajor, M.D. 1st Department of Surgery, Semmelweis University, Budapest, Hungary Attila Zsirka-Klein, M.D. 1st Department of Surgery, Semmelweis University, Budapest, Hungary Oszkár Hahn, M.D., Ph.D. 1st Department of Surgery, Semmelweis University, Budapest, Hungary

1. Mourtzakis, M., et al., A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab, 2008. 33(5):p.977-1006. 2. World Health Organization, Obesity: Preventing and Managing the Global Epidemic. In: Technical Report Series no894., 2000. 3. W. Shen et al.: Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image. Journal of Applied Physiology, 2004, 97, 6, 2333-2338.