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Keywords:
Neuroradiology brain, MR, Diagnostic procedure
Authors:
S. Iafrate, L. Panebianco, S. Quarchioni, L. Patriarca, M. Varrassi, A. Splendiani, C. Masciocchi; L'Aquila/IT
DOI:
10.1594/ecr2017/B-0182
Purpose
Multiple Sclerosis is a chronic,
demyelinating immune‑mediated disease of the central nervous system affecting white and grey matter[1].
The most common age affected by this disease is from 20 to 40 years and the prevalence is 1.1 million people in the world [2].
Many studies hypothesized that cognitive disability is associated with the extent of white matter (WM) lesion load in MS patients but extensive gray matter (GM) loss has been widely reported in patients with MS,
including cortical and deep GM.
[3]
In this study,
we aimed to investigate the subpial cortical demyelination (SCD),
in patients affected by recent-onset multiple sclerosis (MS).
A growing body of evidence shows that subpial cortical demyelination (SCD) is associated with demyelinated cortex in patients affected by multiple sclerosis (MS).
SCD is also found in biopsy cases with early MS and in experimental model.
Recently,
it has been shown that local meningeal inflammatory cells infiltrations contributes to the pathogenesis of SCD.