SS and LS values in healthy volunteers:  We included 39 healthy volunteers (21 males and 18 females) as controls in our study who had no history of chronic liver disease, normal serum liver enzyme levels, and normal findings on abdominal ultrasonography. The mean value of spleen stiffness by ARFI in normal individuals was 2.04 (+/- 0.35) m/s and that of liver stiffness was 1.32 (+/- 0.53) m/s.

SS and LS values in cirrhotic patients without and with EV: Out of 78 patients with liver cirrhosis included in the analysis, 55 (70.5%) patients (45 males, 10 females) were detected to have EV on endoscopy, while EV were absent in rest of the 23 (29.5%) patients (21 males, 2 females). The group of patients with EV was subdivided according to grades of EV on endoscopy. There were 18 (23.1%) patients (16 males, 2 females) with grade 1 EV, 15 (19.2%) patients (11 males, 4 females) with grade 2 EV, and 22 (28.2%) patients (18 males, 4 females) with grade 3 EV.

The mean value of SS in cirrhotic patients without EV was 2.78 (+/- 0.38) m/s (figure 8) and that of LS was 1.91 (+/- 0.51) m/s (figure 10). In cirrhotic patients with EV, the mean value of SS was 3.34 (+/- 0.34) m/s (figure 8) and that of LS was 2.47 (+/- 0.56) m/s (figure 10). In the further subdivided groups, the mean values of SS in patients with grade 1, 2 and 3 EV were 3.09 (+/- 0.35) m/s,  3.36 (+/- 0.31) m/s and 3.54 (+/- 0.32) m/s respectively (figure 9). The mean values of LS in patients with grade 1, 2 and 3 EV were 2.72 (+/- 0.55) m/s, 2.51 (+/- 0.52) m/s and 2.25 (+/- 0.60) m/s respectively (figure 11).

Fig. 8: SS IN PATIENTS WITH AND WITHOUT EV. The mean value of SS in cirrhotic patients with EV was 3.34 (+/- 0.34) m/s whereas in those without EV it was 2.78 (+/- 0.38) m/s.

Fig. 9: SS IN DIFFERENT GRADES OF EV The group of patients with EV was subdivided according to grades of EV on endoscopy. The mean values of SS in patients with grade 1, 2 and 3 EV were 3.09(+/- 0.35) m/s, 3.36 (+/- 0.31) m/s and 3.54 (+/- 0.32) m/s respectively.

Fig. 10: LS IN PATIENTS WITH AND WITHOUT EV. The mean value of LS in cirrhotic patients with EV was 2.47 (+/- 0.56) m/s whereas in those without EV it was 1.91 (+/- 0.51) m/s.

Fig. 11: LS IN DIFFERENT GRADES OF EV The group of patients with EV was subdivided according to grades of EV on endoscopy. The mean values of LS in patients with grade 1, 2 and 3 EV were 2.72 (+/- 0.55) m/s, 2.51 (+/- 0.52) m/s and 2.25 (+/- 0.60) m/s respectively.

There was a statistically significant difference (p < 0.05) in ARFI values of SS between patients with and without EV. Using a cut off  value of 2.60 m/s for ARFI of spleen, SS had a sensitivity of 98.2% , specificity of 34.8 % , PPV of 87.1 % and NPV of 93.8 % for differentiating those with EV from those without EV (Table 1). A cut off value of  3.04 m/s for ARFI of spleen showed a sensitivity of 78.2 % , specificity of 78.3 % , PPV of 89.5 % and NPV of 60 % for differentiating those with EV from those without EV (Table 1). The area under ROC curve for SS was 0.809 (figure 12).

Table 1: STATISTICAL ANALYSIS VALUES FOR SS

For ARFI of liver with a cut-off value of 1.50 m/s, LS showed a sensitivity of 94.5%, specificity of 39.1%, PPV of 78.8% and NPV of 75.0% (Table 2). At a cut-off value of 2.07 m/s, LS had a sensitivity of 76.3%, specificity of 65.2%, PPV of 84.0% and NPV of 53.6% (Table 2). The area under ROC curve for LS was 0.730 (figure 13).

Table 2: STATISTICAL ANALYSIS VALUES FOR LS

Fig. 12: ROC CURVE FOR SS (AUROC= 0.809)

Fig. 13: ROC CURVE FOR LS (AUROC= 0.730)