Among the 247 cancers reviewed,
there were 208 invasive ductal carcinomas (IDC),
36 invasive lobular cancers (ILC) and 3 malignant phyllodes tumors.
The distribution of the density pattern of the breasts was as follows:
ACR a: 6 (2.4%)
ACR b: 108 (43.7%)
ACR c: 103 (41.7%)
ACR d: 30 (12.1%)
Fig. 1: Distribution of breast density patterns in our sample
The distribution of the immunohistochemical patterns of the lesions was as follows:
Luminal A: 127 (51.4%)
Luminal B: 80 (32.4%)
Pure Her-2: 9 (3.6)
Triple negative: 31 (12.6 %)
Fig. 2: Distribution of immunohistochemical patterns of the tumors.
The mean size of the tumors was 15,29 mm (1-95 mm)
For the whole sample,
sensitivities were:
Mammography alone (MX): 53.8%.
Mammography plus US (MXUS): 87%
Mammography plus DBT (MXDBT): 75.7%
Mammography plus US plus DBT (MXUSDBT): 91.5%
Fig. 3: Summary of the sensitivities of the three techniques in our sample, according to the immunohistochemical pattern
Using the McNemar test,
we obtained the following comparisons:
Fig. 4: Performance of the different combinations of diagnostic techniques in all tumors.
According to the immunohistochemical pattern,
sensitivities of mammography (MX),
mammography plus US (MXUS) and mammography plus DBT (MXDBT),
were:
Luminal A cancers
Mammography alone (MX): 46%.
Mammography plus US (MXUS): 84%
Mammography plus DBT (MXDBT): 78%
Mammography plus US plus DBT (MXUSDBT): 92%
Using the McNemar test,
we obtained the following comparisons:
Fig. 5: Performance of the different combinations of diagnostic techniques in Luminal A tumors.
Case 1 depicts a Luminal a tumor in which only DBT was diagnostic:
Fig. 8: Case 1: Luminal A tumor only detected by DBT.
Luminal B cancers
Mammography alone (MX): 60%.
Mammography plus US (MXUS): 90%
Mammography plus DBT (MXDBT): 74%
Mammography plus US plus DBT (MXUSDBT): 90%
Using the McNemar test,
we obtained the following comparisons:
Fig. 6: Performance of the different combinations of diagnostic techniques in Luminal B tumors.
Case 2 depicts a Luminal B tumor only detected by US:
Fig. 9: Case 2: Luminal B tumor only detected by US.
Non-Luminal cancers
Mammography alone (MX): 65%.
Mammography plus US (MXUS): 92.5%
Mammography plus DBT (MXDBT): 72.5%
Mammography plus US plus DBT (MXUSDBT): 92.5%
Using the McNemar test,
we obtained the following comparisons:
Fig. 7: Performance of the different combinations of diagnostic techniques in Non-Luminal tumors.
Case 3 depicts a non-Luminal tumor only detected by US:
Fig. 10: Case 2: Non-Luminal tumor only detected by US.