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Keywords:
Liver, Abdomen, Ultrasound, Elastography, Diagnostic procedure, Cirrhosis
Authors:
G. Ferraioli, L. Maiocchi, R. Lissandrin, A. De Silvestri, C. Tinelli, C. Filice; Pavia/IT
DOI:
10.1594/ecr2017/B-1248
Methods and materials
This was a single center cross-sectional study.
Between January and September 2016,
consecutive patients affected by chronic viral hepatitis referred for liver stiffness measurement (LSM) with the FibroScan device (Echosens,
Paris,
France),
who also voluntarily accepted to undergo LSM with SWM,
were prospectively enrolled.
The study protocol was approved by the institutional Ethics Committee and it was in accordance with the Helsinki Declaration of 1975,
as revised in 2008.
Informed written consent was obtained from each subject for inclusion in the study.
Two trained physicians obtained SWM values using the HI VISION Ascendus system (Hitachi Ltd.,
Japan) with a convex broadband probe.
Measurements were performed in the right lobe of the liver through intercostal spaces following the recommended procedure for pSWE [1].
For each patient,
the measurements of liver stiffness were consecutively obtained at the same location.
In each patient,
10 valid measurements were obtained and the median value,
expressed in kiloPascal (kPa) was used for statistical analysis.
LSMs with the FibroScan device were performed following the examination procedure previously described [2].
For staging liver fibrosis we used the TE cutoffs of a previous meta-analysis,
i.e.
7.0,
9.5 and 12.0 kPa,
for significant fibrosis (F ≥ 2),
severe fibrosis (F ≥ 3) and cirrhosis (F = 4),
respectively [3].
The diagnostic performance of the SWM method was assessed by calculating the area under the receiver operating characteristic (AUROC) curve.