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Keywords:
Outcomes analysis, Imaging sequences, MR-Diffusion/Perfusion, MR, Pelvis, Oncology, Diagnostic procedure, Neoplasia, Outcomes
Authors:
L. Basso, L. Secondini, S. Barbagallo, I. Verardo, C. bergaglio, F. Rosa, C. E. Neumaier; Genova/IT
DOI:
10.1594/ecr2017/C-0705
Aims and objectives
Since to the start,
Diffusion Weighted images in mp-MRI showed its potential in Prostate Cancer (PCa) detection.
Especially,
many studies demonstrated correlation of post-processing Apparent Diffusion Coefficient (ADC) to tumour aggressiveness expressed as Gleason Score (GS) [1].
On the other hand,
the use of contrast introduced and standardized by the Pi-RADS v1 has been recently reviewed in Pi-RADS version 2,
changing the interpretation of contrastographic behaviour of suspected lesions [2].
Nowadays there isn’t a quantitative parameter on Dynamic Contrast Enhanced (DCE-MRI) that strongly relates to GS similarly to ADC [3].
Moreover,
due to the rising incidence of PCa,
some study groups started theorizing the feasibility of a biparametric protocol omitting DCE,
since it seems only to confirm what has already seen on DWI and T2WI [4].
The aim of this study is to compare ADC and Time To Peak (TTP) to aid in discriminating neoplastic lesion according to different GS and quantitatively evaluate the usefulness of DCE-MRI for aggressiveness assessment of prostate cancer.