Learning objectives
The aim of our study is to describe the main HRCT features of Usual Interstitial Pneumonia(UIP),
Interstitial Non-Specific Pneumonitis (NSIP) and Hypersensitivity Chronic Pneumonitis (HP).
Background
UIP,
NSIP and HP are interstitial lung diseases which share some clinical,
radiologicaland histological features.
Being able to recognize the typical findings through HRCT,
is important in order to make the right diagnosis.
Findings and procedure details
UIP
UIP (Usual Interstitial Pneumonia),
typical pattern of IPF (Idiopathic Pulmonary Fibrosis),
is the commonest pulmonary interstitial disease,
with the worst prognosis compared to other pulmonary diseases.
Epidemiology: UIP affects adults older than 50 years[1],
especially men[2],
with an incidence of 2.5 - 3/100.000 inhabitants[3]; risk factors include cigarette smoke,
environment pollution,
working exposition to inhalants agents such as asbestos,
metals and winged animals.
There is also a possible involvement of groups of genes[4].
There are two forms: idiopathic and secondary.
Clinical features: UIP is...
Conclusion
Differential diagnosis between UIP,
NSIP and HP represents,
even nowadays,
a very important challenge,
because of the different outcomes and therapeutic strategies [21]; only through correct diagnostic procedures followed by clinical and anamnestic data integration and correct interpretation of radiological findings can we achieve an opportune diagnosis.
HRCT has a key role in differential diagnosis and in decisional processes,
It makes an important contribution in the decision to perform a lung biopsy.
HRCT has a central role in a context where an interdisciplinary team,
which...
Personal information
Dr.
Modica Alessandro,
Radiology Resident,
University of Catania,
[email protected];
Dr.
Calcagno Maria Carla,
Radiology Resident,
University of Catania,
[email protected];
Dr.
Iudica Giovanna,
Radiology Resident,
University of Catania,
[email protected];
Dr.
Conte Marco,
Radiology Resident,
University of Catania,
[email protected];
Dr.
Anzalone Maria José,
Radiology Resident,
University of Catania,
[email protected];
Dr.
Vizzini Ilenia,
Radiology Resident,
University of Catania,
[email protected];
Dr.
Mauro Letizia Antonella,
Radiodiagnostic and Radiotherapy Unit,
University Hospital "Policlinico - Vittorio Emanuele" Catania,
[email protected];
Prof.
Vancheri Carlo,
Regional Centre for Interstitial and Rare Diseases,
Department of Clinical...
References
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Fernández Pérez ER,
Daniels CE,
Schroeder,
St.
Sauver J,
Hartman TE,
Bartholmai BJ,
Yi ES,
Ryu JH.
Incidence,
prevalence,
and clinical course of idiopathic pulmonary fibrosis.
A population-based study.
Chest 2010; 137(1).
2.
Caminati A,
Madotto F,
Cesana G,
Conti S,
Harari S.
Epidemiological studies in idiopathic pulmonary fibrosis: pitfalls in
methodologies and data interpretation.
Eur Respir Rev 2015; 24: 436-444.
3.
Harari S,
Madotto F,
Caminati,
Conti S,
Cesana G.
Epidemiology of Idiopathic Pulmonary Fibrosis in Northern Italy.
PLOS
ONE 2016.
4.
Piciucchi...