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Keywords:
Breast, MR-Diffusion/Perfusion, MR, Comparative studies, Cancer
Authors:
M. Wielema, M. D. Dorrius, H. Dijkstra, E. Langius, M. Oudkerk, P. E. Sijens; Groningen/NL
DOI:
10.1594/ecr2017/C-2765
Conclusion
The purpose of this study was to compare the reproducibility and diagnostic use of the currently most widely applied ROI method featuring coverage of the entire lesion,
to three alternative methods comparing the ADC values in ROIs standardized by fixing both size and shape.
Any of the alternative ROI methods,
featuring either fixed-size ROIs in the middle of the lesion (ROI2,
0.3 cm2) or ones at lowest ADC (ROI3,
0.3 cm2; ROI4 (0.6 cm2),
yielded strong inter- and intra-observer agreements,
similar to those of ROI1.
In conclusion,
these preliminary results showed that the ADC values derived from fixed size and shape ROIs covering the geometric center of breast lesions or subregions of minimal ADC are equally reproducible as whole lesion ROIs.
Our very small proof-of-principle study indicates that minimum ADC subregions of fixed size and shape allow for improved differentiation between malignant and benign lesions.
These results should be validated in a larger group of breast lesions and in prospective study.