Keywords:
Breast, Abdomen, Oncology, MR, Ultrasound, Mammography, Screening, Diagnostic procedure, Biopsy, Cancer, Radiotherapy techniques, Tissue characterisation
Authors:
J. C. Benson, P. Bolan, M. Nelson; Minneapolis, MN/US
DOI:
10.1594/ecr2018/C-0119
Methods and materials
Patient Selection and Imaging
17 patients underwent breast biopsies with subsequent placement of a VizMark breast marker.
As part of a related multicenter and institutional-wide breast cancer study protocol,
all patients were treated with a 4-month multi-drug neoadjuvant chemotherapy regimen.
Follow-up imaging was completed 2-,
4-,
and 6-weeks following the initiation of neoadjuvant chemotherapy,
also according to the guidelines of the ongoing chemotherapy trial.
An MRI was subsequently completed following surgical excision of the residual tumor.
4 ultrasound and 3 digital mammogram examinations were additionally completed during the 4-month chemotherapy course.
Surgical excision and follow-up
Prior to surgical excision,
the residual tumor bed was localized using the VizMark clip.
All (17/17) patients underwent wire localization using Kopan’s wire technique.
Lumpectomies were completed on each patient,
and specimen radiography was used to confirm removal of the VizMark clip.
Pathology specimens were obtained during the initial biopsy and at the time of definitive surgical excision following neoadjuvant chemotherapy.
Operative notes were utilized to assess the accuracy of guidewire placement within the tumoral bed.
The presence of positive or negative margins during surgical excision was recorded based on final pathology reports.
Tumors were tested for the presence or absence of estrogen receptor (ER+/ER-),
progesterone receptor (PR+/-),
and human epidermal growth factor receptor (HER2 +/-).