Keywords:
Metastases, Ablation procedures, MR-Diffusion/Perfusion, MR, Oncology, Liver
Authors:
O. W. Kozak1, T. Nowicki2, J. Pienkowska2, E. Izycka-Swieszewska2, D. Zadrozny2, E. Szurowska2; 1Gdańsk, po/PL, 2Gdansk/PL
DOI:
10.1594/ecr2018/C-1544
Aims and objectives
The liver is one of the most common metastatic sites of colorectal cancer,
nearly 50% patients develop hepatic metastases during the disease.
Metastatic spread influences survival rate of those patients.
The diffusion-weighted imaging (DWI) is MRI sequence designed to detect random movement of water protons in the extracellular compartment.
Biophysical parameter expressing the flexibility of Brownian motion is the apparent diffusion coefficient (ADC).
ADC values for b parameter lower than 300 s/mm2 are influenced by perfusion whereas ADC values for b greater than 300 s/mm2 depend mainly on diffusion.
The aggressive malignant process often develops necrotic areas within a neoplastic lesion.
Necrotic changes are characterized by high ADC values [1,2].
We suppose that low ADC values correlate with the presence of necrosis in highly malignant lesions effecting in lower survival rate.
This is a post hoc analysis of prospective study [3] to assess the predictive value of the ADC in survival outcomes of patients undergoing radiofrequency ablation (RFA) due to metastatic colorectal cancer lesions in the liver.