Keywords:
Musculoskeletal system, Extremities, Paediatric, CT-Quantitative, Comparative studies, Screening, Osteoporosis, Metabolic disorders, Haematologic diseases
Authors:
A. Balanika, P. XAFAKI, C. Baltas, H. Pergantou, H. PLATOKOUKI, N. L. Kelekis, O. Papakonstantinou; Athens/GR
DOI:
10.1594/ecr2018/C-1605
Conclusion
Haemophilia is a bleeding disorder in which there is impairment of blood clotting or coangulation control.In bleeding disorders there is an increase of haematopoietic growth factors that provokes osteoclasts proliferation,
bone absortption and a negative influence in bone mass.
Reduced bone mineral density in children with haemophilia is multi-factorial and it predisposes to the presence of osteoporosis later in life .The main causes of low bone mass in haemophilia include limited physical activity ,muscle hematomas and atrophy,
joint deformities and arhtropathy.
Our result showed a significant increase of TBD at the right radius probably due to the effect of the hand dominance .The significantly increased TBD at the left tibia should be explained by asymmetrical natural functional differences between the lower extremities.
Boccalandro et al at their study have found also a greater body load on the left foot of haemophilic boys independently from the hand side dominance.
Our haemophilic boys showed statitistical significantly decreased TBD in target –joint probably due to the recurrent bleedings ,
the increasing osteoclastic activity and bone resorption.
The low bone quality and geometry of the limbs in inhibitors FVIII would reflect a failure in bone adaptation to poor musculature due to hematomas.