Keywords:
Musculoskeletal system, Extremities, Paediatric, CT-Quantitative, Comparative studies, Screening, Osteoporosis, Metabolic disorders, Haematologic diseases
Authors:
A. Balanika, P. XAFAKI, C. Baltas, H. Pergantou, H. PLATOKOUKI, N. L. Kelekis, O. Papakonstantinou; Athens/GR
DOI:
10.1594/ecr2018/C-1605
Results
Statistical analysis
pQCT bone parameters were compared between left and right with the paired t-test,
while between children with and without inhibitors and between target and no-target joint with the independent samples t-test.
The level of significance was set at the 0.05 level.
Thirty one children with haemophilia A (severe 24,
moderate 6,
mild 1, mean age 11,2 years range: 6-19) were included in the study.
An arm target-joint (elbow: 3 left/2 right) was found at 5 children while12 children,
at least one leg target-joint was found at 12 children (hip,
knee or ankle: 6 left/ 6 right) .
A past history of FVIII inhibitor (4 of them high responding) was found at 7 children (22.6%) and all had been successfully treated with Immune Tolerance Induction (ITI) in a period of 4-24 months.
All parameters matched for age,
height and weight.
TBD values were significantly higher in right radii than in left (p<0.015) ).
In 5 elbow target joints subjects,
radius TBD values were significantly lower ipsilaterally,
than in non-target hand (186.6±60.4 vs 218.6±39.8,
p<0.05).
Radius TBD values at left hand target joint subjects were significantly lower compared to non-target hand group (155.4±50.3 vs 215.7±37.9,
p<0.05).
There was no similar difference in leg target joints group.
Location-specific bone material properties were significantly lesser in inhibitor versus non inhibitor group,
with statistically significant side-to-side differences for legs and arms and left side predominance.