Keywords:
Oncology, Pancreas, Abdomen, CT, Image manipulation / Reconstruction, Outcomes analysis, Cancer
Authors:
E. Raimondi1, K. Young2, K. Kouvelakis2, D.-M. Koh2, V. Calamai2, N. Starling2, M. A. Bali2; 1Ferrara/IT, 2London/UK
DOI:
10.1594/ecr2018/C-2169
Conclusion
Radiological follow-up of cytotoxic systemic treatment for PDA is currently sustained by dimensional criteria that don’t take into account intra-lesional structural changes treatment-related that could reflect drug efficacy.
The aim of this study was to explore the potential relationship between CTTA metrics and their changes throughout therapy follow-up with response categorization by RECIST 1.1.
According to our preliminary results,
CTTA metrics values measured at BL and FA showed no significant difference between responders and non-responders by RECIST 1.1 in both LAPC and MPC groups and as such they didn’t show any predictive value in terms of response.
Changes in CTTA derived entropy and uniformity from BL to BR were significantly different between responders and non-responders in LAPC patients,
suggesting their relationship with treatment-induced changes within the primary tumour,
whereas no similar results were found in MPC patients.
Overall,
these observations may suggest different biological behavior between locally advanced and metastatic pancreatic cancer.
Indeed,
these are preliminary results,
which need to be further confirmed in large patient cohort.