Keywords:
Oncology, Pancreas, Abdomen, CT, Image manipulation / Reconstruction, Outcomes analysis, Cancer
Authors:
E. Raimondi1, K. Young2, K. Kouvelakis2, D.-M. Koh2, V. Calamai2, N. Starling2, M. A. Bali2; 1Ferrara/IT, 2London/UK
DOI:
10.1594/ecr2018/C-2169
Results
A total of 32 LAPC patients and 35 MPC patients were enrolled in this study.
According to RECIST 1.1 criteria,
in the LAPC group,
responders were 12/32 (37.5%) and non-responders were 20/32 (62.5%) and in the MPC group,
responders were 12/35 (34.3%) and non-responders were 23/32 (65.7%).
In both LAPC and MPC,
CTTA metrics registered at BL and FA showed no significant differences between responders and non-responders.
In the LAPC group,
a significant difference (p < 0.001) between responders and non-responders was found for percentage change in entropy and uniformity from BL to BR; responders showed a median change in entropy of -9.36% (IQR: -13.88%,
-4.07%) and a median change in uniformity of +50.35% (IQR: +19.39%,
+94.27%),
whereas non-responders showed a median change in entropy of +0.36% (IQR: -1.62%,
3.05%) and a median change in uniformity of -5.58% (IQR: -12.92%,
10.71%).
The ROC curves showed no adequate cut-off for percentage change in entropy to differentiate responders from non-responders,
whereas a cut-off value of percentage change in uniformity of +29.33% showed a sensitivity and specificity of 75% and 94.74% respectively (Figure 3).
No statistically significant differences were observed for percentage changes calculated between BR and PD (Entropy: p=0.06; Kurtosis: p=0.19; Uniformity: p=0.17).
In the MPC group,
no significant differences of CTTA metrics percentage changes calculated between BL and BR (Entropy: p= 0.30; Kurtosis: p= 0.76; Uniformity: p= 0.32) and between BR and PD (Entropy: p=0.68; Kurtosis: p=0.75; Uniformity: p=0.30) for responders and non-responders were observed.
Table 1 shows median and IQR values for percentage changes from BL to BR and from BR to PD calculated for responders and non-responders in LAPC and MPC patient groups.