Keywords:
Cardiac, Cardiovascular system, Paediatric, MR, MR-Functional imaging, Echocardiography, Diagnostic procedure, Experimental investigations, Imaging sequences, Congenital, Hyperplasia / Hypertrophy, Genetic defects
Authors:
D. Curione, E. Rossi, M. C. Matteucci, T. Santangelo, P. Ciliberti, P. Toma, A. Secinaro; Rome/IT
DOI:
10.1594/ecr2018/C-2935
Methods and materials
17 paediatric patients,
including 7 males and 10 females (age range 8-34 years,
mean 16 years),
were prospectively selected.
The patients were divided into two subgroups:
- 7 nephropathic subjects;
- 10 normal controls.
All patients underwent 1.5 T CMR comprising native T1-mapping MOLLI sequences,
which consisted of one 4-chamber view and three short-axis slices (basal,
midventricular,
and apical).
These sequences are equipped with a motion correction (MOCO) algorithm in order to reduce respiratory artefacts,
which are frequently found in children.
Image analysis:
- a global myocardial native T1 value was obtained for every patient by placing a region of interest (ROI) in each cardiac segment (according to the AHA classification) and by calculating the overall mean.
A dedicated software (Circle CVI42) was also used to analyse myocardial native T1 mapping images (Fig. 1),
obtaining the mean values for each segment and the overall mean values for each slice/patient.
- the mean myocardial native T1 values and other standard CMR parameters,
including ventricular ejection fraction,
mass,
end-diastolic and end-systolic volumes,
were then compared between the two groups.