Keywords:
Cardiac, CT-Angiography, Computer Applications-3D, Biological effects
Authors:
S. Borzsák, B. Szilveszter, M. Kolossvary, Z. DROBNI, A. Jermendy, A. D. Tarnoki, G. Jermendy, B. Merkely, P. Maurovich-Horvat; Budapest/HU
DOI:
10.1594/ecr2018/C-3122
Methods and materials
We measured LV mass of 190 healthy monozygotic (MZ,
58 pair) and dizygotic (DZ,
37 pair) twins who underwent 256-slice CT angiography.
We measured LV myocardial mass and end-diastolic volumes (EDV) using a semi-automated software.
Epi- and endocardial contours were corrected manually,
when necessary (Fig. 3 Fig. 1Fig. 2).
We adjusted LV mass for body surface area in further calculations.
All continuous variables were expressed as mean ± SD.
We carried out structural equation modeling to decompose the inter-twin variance into environmental and genetic effects using the univariate ACDE models.
As C and D factors cannot be simultaneously estimated,
ACE and ADE models were calculated separately.
We calculated the additive genetic component (A),
the common environmental component (C),
the dominant component (D) and the unique environmental component (E).
We compared the fit of the saturated ACE or ADE models to their nested submodels on the basis of likelihood-ratio test.
Models were corrected for age,
sex and hypertension.
[11] P values <0.05 are considered significant.
Data analysis was performed using SPSS version 24 and R version 3.4.3.