Keywords:
Liver, MR, Diagnostic procedure, Haematologic diseases
Authors:
A. Ugarte1, J. Zubicaray Salegui2, C. Vallejo 2, E. salvador2, J. I. Emparanza1, J. M. Alústiza1; 1San Sebastian/ES, 2San Sebastián/ES
DOI:
10.1594/ecr2018/C-3155
Aims and objectives
Pre and post allo transplant iron overload (IO) has been associated with considerable long-term morbility and mortality1,2.
Classically,
its management has been based in therapeutic phlebotomies (TP),
often inconvenient and not feasible due to ongoing anemia.
Therefore,
it is crucial to diagnose IO before allogenic hematopoietic stem-cell transplant (allo-HSCT).
Serum ferritin (SF) level is widely used to assess IO but its elevation might be nonspecific.
Measurement of liver iron concentration (LIC) by MRI has been proved to be a noninvasive and reliable technique to evaluate iron overload.
The purposes of our study were:
1) To analyze the correlation between transfused packed red blood cells (PRBC),
SF and liver iron concentration (LIC) before allo-HSCT.
2) To estimate in which patients a liver MRI is useful to assess pre-allo-HSCT IO.