Aims and objectives
Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in females worldwide (1).
Due to its excellent soft tissue contrast,
magnetic resonance imaging (MRI) has been established as the best imaging modality for staging of cervical cancers (2).
Thus it is widely clinically used for local tumor staging for this entity.
radiological images can further be investigated quantitatively by advanced imaging analyses.
One of these techniques is a histogram based approach (3).
This method includes every...
Methods and materials
18 female patients (age range 32-79 years; mean age 55.4 years) with histopathological confirmed squamous cell cervical carcinoma were enrolled into the study.
In all cases,
pelvic MRI was performed.
Our investigation protocol included the fllowing sequences: an axial T2 weighted (T2w) turbo spin echo (TSE) sequence (TR/TE: 5590/105),
a sagittal T2w TSE sequence (TR/TE: 4110/131),
an axial T1 weighted (T1w) TSE sequence (TR/TE:1310/12),
an axial T1 TSE sequence after intravenous application of contrast medium (0.1 mmol/kg body weight Gadobutrol,
An overview about the Spearman's correlation analysis with Benjamini-Hochberg correction is given by figure 7.
Several pre- and postcontrast derived t1-weighted parameters correlated inversely with EGFR expression.
For precontrast t1- weighted images,
the strongest correlation was found for p90 (ρ=-0.77,
For postcontrast t1 weighted images,
the strongest correlation was observed for minimum (ρ=-0.64,
p=0.021) (figure 8).
For t2 weighted images,
p90 and median correlated with EGFR expression.
No statistically significant correlations were identified between histogram analysis parameters and cell...
The purpose of this study was to elucidate possible associations between histogram analysis derived from morphological MRI sequences and histopathological features in uterine squamous cell carcinomas.
thepresent study showed that histogram analysis can provide crucial information for tumor characterizing.
Histogram analysis parameters of T1w and T2w images reflect Her2-status and EGFR expression in cervical cancer butcannot predict cell count,
proliferation index or angiogenesis related histopathological features.
Department of Diagnostic and Interventional Radiology
University of Leipzig
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