Keywords:
Outcomes, Neoplasia, Cancer, Staging, MR-Diffusion/Perfusion, MR, Neuroradiology brain, CNS
Authors:
E. Soligo1, S. Gangi1, A. Trisoglio1, S. Berardo2, L. SUKHOVEI 1, A. Stecco1, A. Carriero3; 1Novara/IT, 2Novara, Italy/IT, 3Novara (NO)/IT
DOI:
10.26044/ecr2019/C-0871
Methods and materials
At the end of the work 152 patients were restropective evaluated but only 52 were enrolled.
They presented diagnosis of glioblastoma multiforme,
complete work-up of imaging,
with pre-operative/post-operative and follow-up imaging,
performed with 1.5 T scanner.
MRI images were performed on a 1.5 T MR scanner (MRI-Philips,
Achieva dStream 1.5T),
with a standard protocol including the following sequences: Diffusion Weighted Imaging (DWI),
with relative ADC map,
Fluid-Attenuated Inversion-Recovery (FLAIR),
T2-weighted Turbo-Spin-Echo (TSE),
T1-weighted Spin-Echo (SE) and,
after contrast agent,
3D T1-weighted Gradient-Echo.
MRI scans were red by two radiologists blinded to degree of surgical resection (total or partial) and to the time between surgery and related following imaging.
To dermine the residual tumor,
contrast-enhancement close the surgical cavity was considered and pattern of enhancement near the cavity was divided in linear or nodular.
Gold standard was considered follow-up MRIs.
To avoid bias of pseudoprogression MRIs performed from one or three months after surgery to > 6 months.
After examinations of imaging,
patients were divided in 4 groups,
sorted by time window after surgery: within 24 hours,
from 25 to 48 hours,
from 49 to 72 hours,
after 73 hours.