Aims and objectives
To assess the diagnostic performance of whole body diffusion
weighted imaging with background suppression (WBDWIBS)
and no contrast agents in
assessment of liver metastasis in
breast cancer patients compared
to enhanced 18 FDG-PET-CT.
Methods and materials
50 patients with pathologically proven
breast cancer having suspicious
liver lesions by ultrasound;
underwent both F-18-FDG PET-CT
The study participants were categorized according to the phase of the disease at the time of presentation into two groups; pretherapy group including pathologically proved breast carcinoma lesions after biopsy or post-lumpectomy (A) ,
and post therapy group including patients who were receiving or had finished therapy (B).
Ethical approval was granted by Institutional Review Board of the NCI before the study started.
Informed consent was...
F-18 FDG PET-CT demonstrated slightly higher
specificity indices than MR-DWIBS while the MRDWIBS
displays higher sensitivity indices than
FDG PET CT.
A high degree of the agreement also
existed between DWIBS and PET CT.
WB-MRI/DWIBS is a promising tool in evaluation of liver
metastasis in breast cancer patient.
Easy technique for detection and assessment of metastasis with no
radiation exposure or contrast agents.
1 Kwee TC,
Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology.
2 Takahara T1,
Van Cauteren M.; Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing,
STIR and high resolution 3D display,
3 Kwee TC1,
Nievelstein RA.; ADC measurements of lymph nodes: inter-...