To describe four different types of temporal nulling patterns of blood, myocardium and spleen. To demonstrate the prevalence of different patterns of nulling in a cohort of biopsy proven cases of amyloidosis.

Time of inversion scout (TIS) sequence, performed to identify the nulling time of myocardium, shows nulling of myocardium before blood pool in cardiac amyloidosis (reversed nulling pattern) as opposed to the normal pattern of nulling i.e blood followed by myocardium and spleen.However, it is important to know the other temporal patterns of nulling of myocardium, blood and spleen as multiple nulling patterns may be seen with cardiac amyloidosis. Although, endomyocardial biopsy is the gold standard for diagnosing cardiac amyloidosis, it is an invasive procedure, prone...

We did a retrospective evaluation of the cardiac MRI scans of 12 biopsy proven cases of cardiac amyloidosis. Cardiac MRI was done on a 1.5T/3T scanner. Sample included 5 males and 7 females. The TIS sequence was run on a 8 mm thick, short axis mid ventricle slice (Flip angle 50°,TI increments from 64 to 695 ms), 15 minutes after contrast injection. Due to the inhomogeneous pattern of nulling of the myocardium, the null point of myocardium was considered as optimal when more then 50...

Abnormal contrast kinetics in cardiac amyloidosis is associated with abnormal nulling patterns. If carefully evaluated, it is a useful non-invasive tool for the diagnosis of cardiac amyloidosis.

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