Keywords:
Breast, Oncology, Mammography, Ultrasound, Comparative studies, Treatment effects, Cancer, Outcomes
Authors:
W. Ahmad1, E. Tahir1, S. Aqeel1, I. ZAHEER2; 1Lahore/PK, 231951/SA
DOI:
10.26044/ecr2019/C-2113
Results
81 out of 225 patients demonstrated pCR which is defined as no residual microscopic or macroscopic tumour foci.
mCR was achieved in 66% of patients and sCR in 60% of patients(Fig.2).
Kappa method was used to calculate the agreement between mammography and sonography in predicting pCR as well as to individually correlate mCR and sCR with pCR.
The sensitivity,
specificity,
PPV,
NPV of mammography in predicting pCR was 65%,
80%,
66% and 79% respectively.
The sensitivity,
specificity,
PPV and NPV of sonography in predicting pCR was 59%,
83%,
68% and 77% respectively.
The sensitivity,
specificity,
PPV and NPV of combined mammography and sonography was 65%,
86%,
72% and 81% respectively(Fig.3-4).
Factors found to be associated with an increased likelihood of pCR include
age < 40
smaller tumors (< 2.0 cm)
ductal histology
high nuclear grade tumours
high rate of cellular proliferation (Ki-67)
estrogen receptor negativity
triple negative subtype
HER2-positive disease