Imaging of Nasopharyngeal cancer and correlation with staging, survival and SNPs in Southeast European patients. New approaches.

Congress:

ECR 2019

Poster Number:

C-2266

Type:

Scientific Exhibit

Keywords:

Head and neck, CT, MR, Diagnostic procedure, Cancer

Authors:

E. T. PSOMA¹, A. Koutras¹, X. G. MAVROPOULOU², G.-A. Koliou¹, K. Papadopoulou¹, L. Kalogeropoulou¹, A. Astreinidis¹, I. Chryssogonidis¹, A. Kalogera-Fountzila¹; ¹THESSALONIKI/GR, ²THESSALONIKI, Macedonia/GR

DOI:

10.26044/ecr2019/C-2266

DOI-Link:

https://dx.doi.org/10.26044/ecr2019/C-2266

Table 1: Table 1. Patient and tumor characteristics

Table 2: Table 2.Frequency of VEGF, EDNRA, FAS and NBS1

Table 3: Table 3a. Associations of VEGF with smoking Table 3b.Associations of VEGF with...

Table 4: Table 4. Associations of EDNRA with “medial pterygoid muscles

Aims and objectives

NPC was initially reported in 1901 and clinically characterized in 1922[1] NPC is a rare human malignancy with an annual rate of 0.1–1.1/100,000 people in Europe and most parts of North America. [2] In contrast, highest incidence rates are noted in Southeast Asia, Southern Asia, Alaska and Mediterranean Basin[3] The distinct difference in the incidence among geographic and population area implies that both environmental factors and genetic susceptibility play roles in the development of NPC [4] NPC is strongly associated with Epstein-Barr virus infection irrespectively...

Methods and materials

A cohort of 60 Greek patients with locally advanced NPC, were retrieved from the Hellenic Cooperative Oncology Group (HeCOG) Tumor Repository and analyzed retrospectively in the Laboratory of Molecular Oncology (MOL, by the Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece). The study population consisted of 47 (78.3%) men and 13 (21,7%) women with median age of 50,2 y , with locally advanced NPC and no distant metastasis. Histology, (biopsy proven from the primary site or from cervical lymph nodes in few cases),...

Results

The median follow-up period was 133.34 months (119.8-147.18) months. Most patients (81.7%) had stage II-III NPC (Fig5) , 43.3% had lateral extension b with no significant difference between overall survival and the degree of extention to the parapharyngeal space (Fig 6) and 7 presented with intracranial involvement. 27 patients had A/C VEGFA-2578, while 45% had C/T VEGF -1498 and 66.1% had A/G FAS -670. (Table 2) CC VEGF -1498 and A/C VEGF -2578 was more frequent in smokers (p=0.043 and p=0.038, respectively) and GG VEGF...

Conclusion

The applications of medical imaging in cancer diagnostics and the developments in imaging technologies and computational approaches have guided the emergence of “radiomics”.The concept of radiomics and texture analysis have been applied in a number of studies, for example on tumor differentiation and tumor prognosis[13] By establishing the associations between genomic phenotype and imaging texture features we try to accomplise the transition from population based to a more personalized approach to guide therapy.

Personal information

1. E.T. Psoma, MD Department of Diagnostic Radiology, Ahepa University Hospital, Thessaloniki Greece Phone: + 2313303489 e-mail : [email protected]

References

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