Keywords:
Neoplasia, Metastases, Localisation, Computer Applications-Detection, diagnosis, Comparative studies, PET-MR, PET-CT, MR-Functional imaging, Pelvis, Nuclear medicine, Genital / Reproductive system male
Authors:
A. Peirano1, I. Verardo2, F. Paparo2, A. Piccardo1; 1Genoa/IT, 2Genova/IT
DOI:
10.26044/ecr2019/C-2878
Conclusion
The bio-distribution of 64CuCl2 seems to be more favorable than that of 18F-Choline,
as it is neither excreted nor accumulated in the urinary tract,
while 18F-Choline is accumulated in the urinary bladder and the vesical activity could hide small accumulations of tracer next to it.
This characteristic of 64CuCl2 enables a better assessment of the pelvis and prostatic bed; moreover,
combining this feature with the precise spatial resolution of mMRI imaging,
an increased possibility of identifying small lesions close to the bladder or vesicourethral anastomosis is achieved.
These data also demonstrate the very high sensitivity of 64CuCl2-PET/MRI even in Patients with PSA < 1 ng/ml.
In this sub-group,
more than 70% of Patients presented a positive Fused-64CuCl2-PET/MRI result,
which was often consistent with local relapse.
In other words,
these patients may still benefit from salvage,
PET/MRI-guided-RT [15].
Fused PET/MRI imaging gives better results than PET/CT and mMRI; we,
therefore,
consider 64CuCl2-PET/MRI a promising tool in the management of Patients with biochemical relapse after prostatectomy or EBRT.