Aims and objectives
The aim of this study is to evaluate the impact of histology in the survival analysis of FDG PET/CT parameters in non-small cell lung cancer (NSCLC) stage I patients treated with Carbon ion therapy (CIT).
CIT has been used as an alternative therapy for stage I NSCLC patients in our university hospital and a few other carbon ion centers in the world for patients unwilling to undergo surgery or are inoperable1.
A previous study2done here has shown an FDG PET/CT parameter namely SUVmax (maximum standardized...
Methods and materials
39 histologically confirmed stage I NSCLC patients (29 male/ 10 females; 71.9+/-8.3 years old) with FDG PET/CT data prior to CIT between June 2010 and October 2016,
were enrolled in this study.
We measured the FDG PET/CT parameters: standardized uptake values (maximum - SUVmax,
peak - SUVpeak,
average - SUVave),
volumetric parameters i.e.
metabolic tumor volume (MTV) and total lesion glycolysis (TLG),
and tumor size (with CT component) using the semi-automatic software,
MTV was calculated bytumor volume having SUV of 2.5 or more...
There were 23 adenocarcinoma (AC) and 16 squamous cell carcinoma (SCC) patients,
and all FDG PET parameters were significantly lower in AC than in SCC (p-value < 0.001),
the difference between the tumor size between two histologies was insignificant ( p-value=0.764).
From this study,
we observed the significant variation in the standard uptake values and volumetric parameters of the FDG PET/CT parameters and this finding suggests that a same cut-off of the FDG PET/CT parameter as used in the previous study may not be practical in terms of stratifying the risk in all histologies (as demonstrated in the table) and thereby the management of the patient may be affected if we ignore the histological differences of the uptake values and volumetric parameters of the FDG.
Carbon-Ion Therapy of Lung Cancer,
Journal of Thoracic Oncology,
2.Katsuyuki Shirai,Takanori Abe,Jun‑Ichi Saitoh,Tatsuji Mizukami,Daisuke Irie,Yosuke Takakusagi,Shintaro Shiba,Naoko Okano,Takeshi Ebara,
Tatsuya Ohno,Takashi Nakano,
Maximum standardized uptake value on FDG-PET predicts survival in stage I non-small cell lung cancer following carbon ion radiotherapy.
Oncology Letter June 2017 Vol.13 Issue 6; 4420-4426