Keywords:
Performed at one institution, Observational, Retrospective, Multidisciplinary cancer care, Cancer, Screening, Outcomes analysis, Health policy and practice, Mammography, Breast
Authors:
H. Gewefel1, L. kassem1, I. Ewais2, K. Shohdy1; 1Cairo/EG, 2Al-Rehab City/ New Cairo/EG
DOI:
10.26044/ecr2020/C-01245
Results
The study included 300 women with median age of 50.7 years at diagnosis (range 21 -78 years). Fifty percent (150 women) were below the age of 50 at time of first diagnosis.
Out of the 300, 33 patients (10.9%) had a mammography detected breast cancer recurrence after a median follow up duration of 49 months (≈4.1 yrs). Twenty patients (60.6%) had ipsilateral recurrence, 8 (24.2%) had contralateral recurrence, and 5 (15.2%) had bilateral recurrence. The majority of these recurrence incidents (70%, 23/33) were reported at the first 5 years after surgery. The earliest recurrence was reported at 2 years interval and the latest reported at 12 years.
The most common reported screening mammography finding was a newly developed suspicious mass as the main finding in 72.7% (24/33), followed by suspicious calcifications in 54.5% (18/33); with or without associated distortion, asymmetry or any suspicious skin changes evident in mammography.
Factors that could predict local recurrence (LR) included positive family history of breast/ovarian cancer ( LR rate was 17% of patients with positive family history versus 7.8% in those with negative family history; p=0.017); less parity (LRR was 19.6% in less than 2 offspring versus 4.7% in women having 2 or more offspring; p=0.002); and lactation duration less than 2 years (LRR was 27.1% in those who lactated for 0-2 years versus 4.4% in those who lactated > 2 years; p<0.001).
In our study population, we observed no statistically significant association between age at presentation, BMI, menopausal status, breast density or the pathological type or stage at diagnosis of the initial disease with the local recurrence rate.