Keywords:
Performed at one institution, Observational, Prospective, Cancer, Diagnostic procedure, MR, Cardiovascular system, Cardiac
Authors:
N. A. Atia1, L. Lehmann2, H. Goldschmidt2, F. André2, J. Salatzki2, M. G. friedrich3, H. Katus2, J. Riffel2; 1Tanta/EG, 2Heidelberg/DE, 3Montreal/CA
DOI:
10.26044/ecr2020/C-03068
Results
So far, we have enrolled 14 patients. Two patients dropped out from the 2nd follow up due to change of chemotherapy regimen or death.
We found that the mean global LV Strain parameters were within normal range at baseline and stable during follow-up. Five patients however showed an increase in the number of abnormal LV segments between baseline and follow-up scans (see Figure 3). Furthermore, at the 2nd follow up three of those patients showed a decrease of LVEF and/or MAPSE which was associated with the appearance of clinical symptoms such as dyspnea or generalized weakness in two of them. The mean RV GCS was significantly reduced in follow-up studies (baseline -17.8±1.6%, 1st -16.5±2.4% & 2nd -14.9±2.7%) indicating a potential effect on RV deformation (P = 0.018) (see Figure 4). Other functional and tissue characterization parameters were within normal range at baseline and during follow-up.
The decrease in RV GCS was not associated with significant increase in cardiac biomarkers (Nt-proBNP, hsTNT) (see Figure 5). Long term follow-up of those patients is needed to determine whether an affection of cardiac deformation is associated with higher cardiac event rates or increase in mortality.