Purpose
Currently, an increase in the incidence of BCG vaccination-induced bone complications (BCG-osteitis) is registered [1-3]. Besides, according to a certain view, the true prevalence of BCG-osteitis is even higher because it is difficult to identify the disease pathogen Mycobacterium bovis (Abayev Yu., 2015). Actually, the early diagnosis and treatment of hematogenous osteomyelitis is associated with the burden of atypical features and suppressed cases of inflammation [4, 5]. Regardless the implemented molecular genetic methods for verification of inflammation, especially in cases of tuberculosis, radiological examination remains...
Methods and materials
Clinical laboratory and x-ray findings of 12 children aged 1-14 years (mean age 6.4 ± 2.6 year) admitted to the orthopedic and surgical in-patient departments were analyzed. The patients were hospitalized because of the suspected bone inflammation. They presented pain in certain portion of limb, redness, soft tissue swelling, limb dysfunction (fig.1); 6 patients injured limb in close history before the symptoms appeared. The acute onset of the disease occurred in 2 (16.7 %) patients with general intoxication phenomena, pain in the affected bone. The...
Results
Comprehensive examination allowed to diagnose BCG-osteitis in 6 (50.0 %) patients, and focal hematogenous osteomyelitis in 6 (50.0 %). 10 patients underwent surgical treatment (bone resection at the level of pathological site with transplant replacement).
The x-ray patterns at BCG-osteitis and non-specific osteomyelitis were quite uniform: X-ray images and computed tomograms demonstrated that the bone lesion looked like homogeneous destruction foci, with locally indistinct, in places clear contours, with sclerotic rim and perifocal bone structure condensation.
The focal localization in case of BCG-associated osteitis was...
Conclusion
Tuberculosis of bones and joints is characterized by subacute and chronic course with corresponding clinical and x-ray pattern.
Nowadays the slow, gradual development of inflammation is the feature of hematogenous osteomyelitis, and x-ray picture is not always typical. The etiology of the process is verified pathomorphologically.
However, clinical picture and x-ray findings must be considered obligatory.
What helps?
All data together: the age of the patient, the developed diagnostic criteria, dynamics, thorough analysis of x-ray findings.
Personal information and conflict of interest
N. Lysenko; Kharkov/UA - Author at KhMAPE O. P. Sharmazanova; Kharkiv/UA - Author at KhMAPE I. O. Voronzhev; Kharkov/UA - Consultant at KhMAPE V. Bayev; Kharkov/UA - Consultant at Sytenko Institute of Spine and Joint Pathology
References
1. Koyama A,Toida I,Nakata S. (2009) Osteitis as a complication of BCG vaccination. 84(3):125-32. https://www.ncbi.nlm.nih.gov/pubmed/19364044
2. Toida I,Nakata S. (2007) Severe adverse reactions after vaccination with Japanese BCG vaccine: a review. 82(11):809-24. https://www.ncbi.nlm.nih.gov/pubmed/18078106
3. TwineC., CoulstonJ., Tayton K. Bony lesions in BCG‐vaccinated children: Consider BCG osteitis. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1754.2007.01064.x
4. Yeo A., Ramachandran M. (2014) Acute haematogenous osteomyelitis in children. BMJ.2014;348:1326.
5. Jaramillo D., Dormans J.P., Delgado J. et al. (2017) Hematogenous Osteomyelitis in Infants and Children: Imaging of a Changing Disease. Radiology: 283(3):629-643.