Effect of Hypertension on Left Ventricular Deformation in uncomplicated Type 2 Diabetes Mellitus Subjects

Congress:

ECR 2020

Poster Number:

C-04460

Type:

Scientific Exhibit

Keywords:

Cardiac, Cardiovascular system, MR, Complications, Contrast agent-intravenous, Decision analysis, Hypertension, Metabolic disorders, Prospective, Cross-sectional study, Performed at one institution

Authors:

J. Li¹, Z.-G. Yang², Y.-K. Guo², X. liu², Y. Gao²; ¹Chengdu, Sichuan/CN, ²Chengdu/CN

DOI:

10.26044/ecr2020/C-04460

DOI-Link:

https://dx.doi.org/10.26044/ecr2020/C-04460

Fig. 1: CMR derived strain findings among controls, T2DM(HT-) group and T2DM(HT+) group

Fig. 2: CMR derived structure and function findings among controls, T2DM(HT-) group and...

Fig. 3: The associations of clinical factors and imaging variables with cardiac...

Purpose

To evaluate how left ventricular deformation is influenced by hypertension, and related clinical and imaging variables in type 2 diabetes mellitus (T2DM) utilizing multiparametric cardiac magnetic resonance (CMR) imaging.

Methods and materials

A total of 50 T2DM patients (23 patients without hypertension [T2DM(HT-)] and 27 patients with hypertension [T2DM(HT+)]) and 22 controls were performed the CMR examination and evaluated in this study. CMR-derived parameters including cardiac geometry, microvascular perfusion, T1 mapping, and strain were analyzed and compared among T2DM(HT-), T2DM(HT+) and controls with adjustment age, sex, and heart rate. The effect of hypertension in T2DM patients were identified in multivariable analyses for associated with LV deformation.

Results

Compared with controls, patients with T2DM showed reduced microvascular perfusion, reduced strain, increased LV remodeling index, and increased extracellular volume (ECV)(figure 1and figure 2). Hypertension contributes to greater deterioration of LV strain and LV remodeling index in T2DM patients after adjustment for covariates, but did not differ in microvascular perfusion and ECV(figure 1and figure 2). In univariable analysis, regardless of coexisting diseases, diabetes and hypertension were significantly correlated with myocardial strain, and longer duration of diabetes and higher systolic blood pressure (SBP) were associated with...

Conclusion

In conclusion, T2DM is related to decreased LV microvascular function, concentric remodeling, myocardial fibrosis and deformation dysfunction, the coexistence of hypertension in diabetes worsens LVcardiac function.

Personal information and conflict of interest

J. Li; Chengdu, SICHUAN/CN - nothing to disclose Z.-G. Yang; Chengdu/CN - nothing to disclose Y.-K. Guo; Chengdu/CN - nothing to disclose X. Liu; Chengdu/CN - nothing to disclose Y. Gao; Chengdu/CN - nothing to disclose

References

Sun D, Zhou T, Heianza Y, Li X, Fan M, Fonseca VA, et al. Type 2 Diabetes and Hypertension:A Study on Bidirectional Causality. Circ Res. 2019;124(6):930–7. 2. Solomon SD, Chew E, Duh EJ, Sobrin L, Sun JK, VanderBeek BL, et al. Diabetes and Hypertension: A Position Statement by the American Diabetes Association. Diabetes Care. 2017;40(3):412–8. 3. Levy BI, Schiffrin EL, Mourad J, Agostini D, Vicaut E, Safar ME, et al. Impaired Tissue Perfusion A Pathology Common to Hypertension , Obesity , and Diabetes Mellitus. Circulation....