-To identify main imaging featuresof the transient lesions of the splenium(TLS). -To define the possible etiologiesand clinical characteristics of TLS. -To be aware of these lesions to differentiate from other causes and particularly to avoid a misdiagnosis of ischemia.

The concept of TLS is first described as a clinicoradiological syndrome by Tada et al. in 2004. TLS have been named by many titles, including reversible splenial lesion syndrome (RESLES), mild encephalopathy with reversible splenial lesions (MERS), clinically silent lesions in the splenium of the corpus callosum, and cytotoxic lesions of the corpus callosum (CLOCCs). It is defined as a clinicoradiological syndrome with encephalopathy shows transient changes mainly in the splenium of the corpus callosum in magnetic resonance imaging (MRI) and mostly recovers in follow...

We retrospectively investigated the patients that show restricted diffusion in splenium of the corpus callosum and their medical history at our institute. Nine patients with the lesion in splenium of the corpus callosum were indicated with MRI findings, mainly restricted diffusion on DWI and ADC map and reversibility on follow up images. In addition, medical history, including clinical signs and symptoms, underlying disease or trauma, previous medication, and operations, were recorded from the medical files. The typical MRI features are transient high signal intensity on...

In the lesions of corpus callosum splenium, MRI follow-up is needed for TLS diagnosis, and underlying causes should be investigated. Awareness of these lesions is necessary as they are rare and they have to be differentiated from other causes affecting the corpus callosum.

M. Sorkun; Istanbul/TR - nothing to disclose B. Baysal; Istanbul/TR - nothing to disclose S. Erdemli; Istanbul/TR - nothing to disclose B. Atalay; Istanbul/TR - nothing to disclose M. B. Eser; Istanbul/TR - nothing to disclose

Tada H, Takanashi J, Barkovich A, et al. Clinically mild encephalitis/ encephalopathy with a reversible splenial lesion. Neurology. 2004;63:1854–8 Starkey J,Kobayashi N,Numaguchi Y,Moritani T. Cytotoxic Lesions of the Corpus Callosum That Show Restricted Diffusion: Mechanisms, Causes, and Manifestations. RadioGraphics. 2017;37:562–576. Pan J, Zhao Y, Lu C, Hu Y, Yang Y.Neurol. Mild encephalitis/encephalopathy with a reversible splenial lesion: five cases and a literature review. BMC Neurology.2017 May 25; 17(1):103. Qing, Y, Xiong, W, Da-xiang Huang, Juan, Z, Fei, W, Yong-qiang Y.Statistical Analysis of the Apparent Diffusion...