To provide an overview on the MRI quantification methods of iron in liver To list the various methods of MR imaging–based liver iron detection and quantification

Iron overload is a systemic disorder and is either primary (genetic) or secondary (exogenous iron administration). Primary iron overload is most commonly associated with hereditary hemochromatosis and secondary iron overload with ineffective erythropoiesis that requires long-term transfusion therapy, leading to transfusional hemosiderosis. Iron overload may lead to liver cirrhosis and hepatocellular carcinoma, in addition to cardiac and endocrine complications. The liver is one of the main iron storage organs and the first to show iron overload. Therefore, detection and quantification of liver iron overload are...

Liver-to-Muscle Signal Intensity Ratio The GRE-based signal intensity ratio technique is based on observation of a signal intensity decrease from T2* shortening in the presence of liver iron overload(Fig.3,7) in comparison with the signal intensity of a unaffected reference tissue , typically the paraspinal muscles. The signal intensity of normal liver parenchyma should always be higher than that of the paraspinal muscles.A hypointense liver relative to the paraspinal muscles indicates iron overload. This is assessed semi quantitatively by measuring the liver-to-muscle signal intensity ratio. In...

Iron overload is a relatively common disease with various causes. Making a clinical diagnosis is often difficult. Knowledge of the imaging findings, the patterns of distribution, and associated diseases can facilitate diagnosis. MR imaging has a fundamental role because it can contribute, in a noninvasive way, to the diagnosis, the estimation of liver iron concentration.

C. Rasagna; Chennai/IN - nothing to disclose F. Abubacker Sulaiman; Chennai, TN/IN - nothing to disclose A. Rajendran; Chennai, TA/IN - nothing to disclose A. Asokan; Kelambakkam/Chennai, TA/IN - nothing to disclose C. Natesan; Chennai/IN - nothing to disclose

1.1.Marcony Queiroz-Andrade, Roberto Blasbalg et al, MR Imaging Findings of Iron Overload RadioGraphics 2009; 29:1575–1589 2.Roxanne Labranche, Guillaume Gilbert, Milena Cerny et al, Liver Iron Quantification with MR Imaging: A Primer for Radiologists RadioGraphics 2018; 38:392–412 3.Christian Rose, Olivier Ernst, Bernard Hecquet, Patrice Maboudou, Pascale Renom, Marie Pierre Noel, Ibrahim Yakoub-Agha, Francis Bauters, Jean Pierre Jouet Quantification by magnetic resonance imaging and liver consequences of post-transfusional iron overload alone in long-term survivors after allogeneic hematopoietic stem cell transplantation Haematologica 2007; 92:850-853 4.Xian Fu Luo, Xue...