Obesity and non-alcoholic fatty liver disease (NAFLD) as a component of metabolic syndrome are currently issues of the urgent interdisciplinary problems in medicine. Despite the presence of a wide range of laboratory and instrumental diagnostic methods, many problems remain. The absence of complaints and changes in laboratory parameters in most patients with NAFLD make it difficult to identify and diagnose this pathology, even with the development of steatosis. Unfortunately the amount of patients agreed to make liver biopsy is rapidly decreasing. Purpose: To assess the...

118 patients aged 19–77 years were examined, 52 of them men (44%) and 66 women (56%) due to a single 7 (8) stages diagnostic algorithm: 1. Questioning and complaints collecting, quality of life 2. Clinical inspection 3. Non-invasive bioimpedancemetry with subsequent assessment of fat mass index 4. Ultrasound liver examination in B-mode 5. Quantitative ultrasound steatometry with ultrasound wave attenuation coefficient evaluation 6. Dual-energy X-ray absorptiometry in the “Whole body” mode 7. Liver biopsy with histological microscopic specimens on SAF and NAS scales assessment. The...

There were no signs of liver steatosis in 4 patients (3.4%) with a clinical picture of metabolic syndrome were detected using instrumental diagnostic methods. All patients were devided into 4 groups according to the histological results: S0 - 10%, S1 - 30%, S2 - 40%, S3 - 20%. The sensitivity and specificity of B-mode were 60.4% and 72.8%, respectively, hepatorenal index - 64,5% and 76,3%, quantitative ultrasound steatometry - 90.7% and 92.4%, dual-energy X-ray absorptiometry in the “Whole body” mode — 88.7% and 90,1%.

Ultrasound steatometry is an informative method for non-alcoholic fatty liver disease screening. The correlation of quantitative ultrasound diagnostics data for steatosis with a biopsy at stage S0 corresponds to r = 0.87; at stage S1 r = 0.69, S2 r = 0.75, at stage S3 corresponds to r = 0.86, which indicates the high informativeness of this method; Dual-energy X-ray absorptiometry in the "Whole body" mode can be used as an alternative to multislice computed tomography to identify components of the metabolic syndrome due to...

D. Venidiktova; Smolensk/RU - nothing to disclose A. Borsukov; Smolensk/RU - nothing to disclose

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