SOS2 clinical trial: 5 year results of a screening program for lung cancer early diagnosis with Chest Digital Tomosynthesis (NCT03645018)

Congress:

ECR 2020

Poster Number:

C-09762

Type:

Scientific Exhibit

Keywords:

Performed at one institution, Observational, Prospective, Cancer, Diagnostic procedure, Biopsy, CT, Conventional radiography, CAD, Oncology, Lung, Computer applications, Chest

Authors:

A. Cerutti¹, I. Baralis², P. Demaria¹, A. Negri³, S. Chauvie¹, A. Demaggi¹, G. Gallarato⁴, R. Priotto⁵, M. Grosso⁴; ¹Cuneo/IT, ²Turin/IT, ³Saluzzo/IT, ⁴Cuneo (CN)/IT, ⁵Madonna Dell'olmo (CN)/IT

DOI:

10.26044/ecr2020/C-09762

DOI-Link:

https://dx.doi.org/10.26044/ecr2020/C-09762

Fig. 1: ROC Curves of DTS and CT for lung nodules in SOS2.

Fig. 2: Interval cancer: patient with right pleural apical thickening in 2011 DTS, with...

Fig. 3: Consort diagram SOS e SOS2.

Purpose

To evaluate lung cancer detection rate at five years in a high risk population previously enrolled in two rounds (baseline and one year) of a lung cancer screening trial (SOS) with chest digital tomosynthesis (DTS).

Methods and materials

1342 subjects were enrolled with a drop out of 23.1%. DTS were independently reported by two radiologists and nodules larger than 5 mm undewent CT. If CT was not resolutive further examination were performed according to 2017 Fleischner Society guidelines. Analysis on interval cancer diagnosed between second and third DTS was conducted.

Results

Positive DTS were 7.2%, 0.7% and 7.6% at first, second and third round. During the third round DTS correctly classified solid nodules density in 84.4% of cases. AUCs in DTS and CT ROC curves were 0.78 (0.68±0.88) and 0.87 (0.80±0.93), respectively. Cancer detection rate was 0.9% at baseline and five years (66.7% received surgery), while at 1 year was 0.3% with 80% surgical approach. Interval cancer were diagnosed in 0.98% of subjects (average 1137 days after last DTS). In 22.2% a negative/invariate nodule at basal...

Conclusion

DTS identify solid opacity and has a comparable AUC to CT. Cancer detection rate was in accordance with Low Dose CT trials results. DTS could be a complementary tool to LDCT if scheduled in an interval between 1 and 5 years in order to design a lung cancer screening.

Personal information and conflict of interest

A. Cerutti; Cuneo/IT - nothing to disclose P. Demaria; Cuneo/IT - nothing to disclose I. Baralis; Turin/IT - nothing to disclose A. Negri; Saluzzo/IT - nothing to disclose M. Grosso; Cuneo (CN)/IT - nothing to disclose R. Priotto; Madonna Dell'olmo (CN)/IT - nothing to disclose G. Gallarato; Cuneo (CN)/IT - nothing to disclose S. Chauvie; Cuneo/IT - nothing to disclose A. Demaggi; Cuneo/IT - nothing to disclose

References

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