To outline the clinical impact of extraosseous multiple myeloma on treatment and prognosis. To describe radiological features of extraosseous multiple myeloma with CT, MRI, PET/CT and Ultrasound examples. To correlate with pathological findings of extraosseous multiple myeloma.

Multiple Myeloma: A malignancy characterized by monoclonal proliferation of mature plasma cells arising in the bone marrow A common hematological malignancy amongst the elderly Signs & Symptoms of Multiple Myeloma: Fatigue Bone Pain Weight Loss Anaemia Renal Impairment Hypercalcaemia Although it remains incurable, treatment is evolving at a rapid rate New therapeutic options include: Thalidomide, Lenalidomide Bortezomib, Stem Cell Transplantation Monoclonal Antibodies. These advancements have led to an increase in survival rate over the past 20 years1. However, the overall prognosis remains poor: 5 year...

MRI, PET CT and CT play an important role in the detection of extraosseous disease. Imaging findings are non-specific and can mimic other disease processes. The exact imaging modality used may be determined by availability and resources7. Commonimaging appearances: Homonogenous, non-calcified, non-necrotic soft tissue mass Low T2 signal on MRI Increased FDG uptake on PET CT Cases of Extraosseous Multiple Myeloma Case 1: 74 year old male with known MM presenting with left upper limb monoplegia, with CT imaging (Fig. 5) showing multiple pulmonary nodules...

Multiple Myeloma remains incurable, but treatment is evolving at a rapid rate. These advancements have led to increased survival rates. The incidence of EO Myeloma has increased; potentially due to the increased survival rates and improved imaging methods. It can manifest virtually anywhere in the body.MRI, PET CT and CT play an important role in the detection of extraosseousdisease. Whilst it is linked with a poorer prognosis, early detection of extraosseous disease isof great benefit to the patient's management.

E. McDermott; Dublin/IE - nothing to disclose S. McEvoy; Dublin/IE - nothing to disclose

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