Learning objectives
Learn about the correlation between MRI features and histological tumor grade.
Background
Soft tissue sarcomas are a very heterogeneous group as well on their histology as their prognosis. The extremities are the site of 50% of soft-tissue sarcomas, with 80% of those occurring in the lower extremities. Malignant fibrous histiocytomas the most common histologic subtype, followed by liposarcoma (1).
Histopathological grade is one of the major factor in the therapeutic management of these tumors. They are classified according to the FNCLCC (Federation Nationale des Centres de Lutte Contre le Cancer) (3) into 3 grade with grade one...
Findings and procedure details
The therapeutics plans of a soft tissue sarcoma relies strongly on the tumoral staging (UICC 8th edition). Criteria that come into account are the tumor size, the presence of lymph node metastasis, the presence of distant metastasis, and the histological grade.
Histological grade of the tumor should be obtain before any pre-operative treatment. Planned core-needle biopsy guided by pre-therapeutic imaging is the preferred method of biospy. It is mandatory to avoid non-involved anatomical compartments and the path of the biopsy must be resected by definitive...
Conclusion
Histologicalgrade of sarcomas predicts metastatic risk and prognosis. Radiologists should therefore be aware of MRI features correlated with high-grade sarcoma and systematically search for them in their analysis. Poorly limited margins, peri-tumoral fluid signal and enhancement are strong criteria associated with high-grade tumors.
Personal information and conflict of interest
S. S. Kolani; Fes/MA - nothing to disclose M. Haloua; Fes/MA - nothing to disclose B. Alami; Fes/MA - nothing to disclose Y. Lamrani; Fes/MA - nothing to disclose M. Boubbou; Fes/MA - nothing to disclose M. Maaroufi; Fes/MA - nothing to disclose
References
1.Pisters PW, et Al. Sarcomas ofsoft tissue. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, eds. Clinical oncology. 3rd ed. New York, NY: Churchill Livingstone, 2004; chap 97.
2.Harcke HT, et Al. Evaluation of the musculoskeletal system with sonography.AJR Am J Roentgenol 1988;150(6):1253–1261.
3.Trojani M, et Al. Soft-tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system. Int J Cancer 1984; 33: 37–42.
4.Dalinka MK, et Al. The use of magnetic resonance imaging in the evaluation...