Keywords:
Cardiac, Haematologic, Pancreas, MR, Outcomes analysis, Statistics, Haematologic diseases, Not applicable, Diagnostic or prognostic study, Multicentre study
Authors:
G. Peritore1, A. Meloni2, L. Pistoia2, N. Giunta1, M. G. bisconte3, V. Positano2, D. Messana1, A. Pepe1; 1Palermo/IT, 2Pisa/IT, 3Cosenza/IT
DOI:
10.26044/ecr2020/C-11050
Purpose
Iron-induced cardiomyopathy is the most common death cause for patients suffering from thalassemic disease, as well as a recurrent finding in multi-transfused patients with acquired anemias. Iron overload-related cardiomyopathy is reversible, but the diagnosis is often delayed due to the late appearance of symptoms and echocardiographic abnormalities
Cardiovascular Magnetic Resonance has an established role in managing and predicting prognosis of patients with Thalassemia Major and has proved to be useful for chelation therapy evaluation in these patients. Thalassemia Intermedia is a milder variant of beta-thalassemia, showing a different clinical and prognostic profile.
In Thalassemia Major patients pancreatic iron was shown to be correlated to cardiac iron, biventricular function and myocardial fibrosis detected by Cardiovascular Magnetic Resonance1,2.
In the present multicenter study we explored the link between pancreatic iron and Cardiovascular Magnetic Resonance parameters in a cohort of patients with Thalassemia Intermedia.