Keywords:
Neoplasia, Contrast agent-intravenous, MR-Diffusion/Perfusion, MR, Oncology, Genital / Reproductive system male, Genitourinary, Prospective, Observational, Performed at one institution
Authors:
S. cipollari1, G. Anello1, F. Giganti2, M. Pecoraro1, D. Fierro1, R. Campa3, M. Del Monte1, C. Catalano1, V. Panebianco1; 1rome/IT, 2London/UK, 3Roma/IT
DOI:
10.26044/ecr2020/C-11563
Methods and materials
A recurrence score was created and achieved through an evidence-based literature search in conjunction with professional experience.
Two radiologists (both with 5 years of experience in prostate mpMRI) prospectively and independently analyzed 65 mpMRI consecutive studies of men after radical prostatectomy with suspicion of prostate cancer (PCa) recurrence and PSA levels of 0.2- 1.5 ng/ml at the time of the exam. The protocol consisted of dynamic contrast enhanced (DCE), T2-weighted (T2W) and diffusion weighted (DWI) imaging, acquired at 3T scan.
Each mpMRI sequence was considered “positive” or “negative” considering the presence or the absence of different suspicious features in each sequence. In case of discordance, the opinion of a third radiologist (with 15 years of experience in prostate MRI) was requested. Sensitivity, specificity, positive and negative predictive value (PPV; NPV) were calculated for both
readers using a 2 × 2 contingency table. The Ƙ-statistic was used to estimate inter-reader agreement. For statistical analysis IBM SPSS Statistics 23.0 was used. Statistical significance was set at p < 0.05.