Purpose
Atherosclerosis in its distinctive manifestations of coronary artery disease, peripheral artery disease (PAD), and cerebrovascular disease constitutes the main cause of morbidity and mortality worldwide.[1] Over the past years, the number of peripheral endovascular procedures to treat symptomatic PAD has been significantly increased not only because of high technical success, low complication rates, and shorter hospitalization time but also because of the percentage of PAD patients with no surgical options or at high surgical risk, mainly due to old age and severe comorbidities.[2-4] In spite...
Methods and materials
Study design and population: Periprocedural bleeding complications occurring within the first 30 days following an endovascular intervention for chronic PAD were recorded in this prospective, single-center study. Bleeding events included retroperitoneal hemorrhage, pseudoaneurysm, vessel perforation, access site hematoma >5cm or requiring surgical treatment, intracranial hemorrhage, or gastrointestinal bleeding. Symptomatic adult patients with PAD were eligible if they met criteria for EVT in our department; suffered from stenosis or occlusion in the lower or upper limb, carotid, or visceral arteries; and gave informed consent for study...
Results
Bleeding complications of peripheral EVT:The overall bleeding complication rate was 3.8% (20/530). Seventeen (3.2%) events were considered major and included active retroperitoneal bleeding in 4 (0.7%) patients and pseudoaneurysms in 13 (2.4%). The three minor complications were individual instances (0.2% each) of vessel perforation, large groin hematoma, and a large hematoma with arteriovenous fistula. One life-threatening retroperitoneal hemorrhage occurred during stent post-dilation in the external iliac artery; it was immediately resolved using a stent-graft. The other three retroperitoneal bleeding events were accessing site-related; in all,...
Conclusion
In this study, periprocedural bleeding complications in peripheral EVT were rare, did not result in death, and were successfully managed without the need for surgery. The specific cohort demonstrated an increased bleeding risk profile. Advanced age and female sex were correlated with increased bleeding risk while patients on statin therapy had reduced bleeding risk. The HAS-BLED score failed to predict bleeding events. PBS values of 4 or less were correlated with decreased bleeding risk. The newly proposed preprocedural PBS is easy to calculate, does not...
Personal information and conflict of interest
A. Tsochatzis; Athens/GR - nothing to disclose S. C. Spiliopoulos; Athens/GR - nothing to disclose G. Festas; Athens/GR - nothing to disclose L. Reppas; Athens/GR - nothing to disclose F. Christidi; Athens/GR - nothing to disclose K. Palialexis; Athens/GR - nothing to disclose E. Brountzos; Haidari/GR - nothing to disclose
References
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2. Kakkar AM, Abbott JD. Percutaneous versus surgical management of lower extremity peripheral artery disease. Curr Atheroscler Rep. 2015;17:479.
3. Spiliopoulos S, Karnabatidis D, Katsanos K, et al. Daycase treatment of peripheral arterial disease: results from a multi-center European study. Cardiovasc Intervent Radiol. 2016;39:1684–1691.
4. Adam DJ, Beard JD, Cleveland T, et al. Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial. Lancet. 2005 366;1925–1934.
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