Type:
Educational Exhibit
Keywords:
Not applicable, Drugs / Reactions, Education, CT-High Resolution, Lung, Chest
Authors:
S. De la mano González, J. C. Paniagua, M. T. Garzón Guiteria, P. Arias Rodriguez, P. García Hernández, B. Prieto García, S. YAÑEZ CASTAÑO, S. Marquez Batalla, R. Rodríguez Vázquez; Salamanca/ES
DOI:
10.26044/ecr2020/C-12546
Background
Drug-induced lung injury is a frequent cause of acute, subacute and chronic lung pathology and is most often caused by cytotoxic drugs.
The prevalence of chemotherapy-induced lung toxicity is increasing with the introduction of new potentially pneumotoxic drugs. The lung lesion can be progressive, so early diagnosis is essential.
The diagnosis of toxicity pneumopathy is of exclusion, and forces to rule out other processes that may coexist especially in the cancer patient.
Radiological findings are usually associated with the underlying histological pattern although some patients show more than one pattern simultaneously. In lung toxicity, various histological subtypes of interstitial lung disease can be observed.
HRCT is more sensitive than chest radiography to define lung pathology but radiological findings are not specific to a particular drug. The only drug reaction that may result in a characteristic appearance on CT is amiodarone.
PET can be a good tool to monitor or even predict lung toxicity.
We have reviewed several cases of drug-induced toxicity through HRCT lung realized in our hospital to illustrate this pathology.