Type:
Educational Exhibit
Keywords:
Performed at one institution, Observational, Retrospective, Metabolic disorders, Statistics, Ultrasound, Liver, Abdominal Viscera
Authors:
A. R. C. Kattoju, C. A. Akeel, D. S. Kattoju; Chennai/IN
DOI:
10.26044/ecr2020/C-13206
Findings and procedure details
Comprehensive analysis of the given data revealed the following findings, The results are classified under various parameters and they revealed that High prevalence of Early fatty liver changes noticed during routine health check up examination of 51612 patients.
A total of 51612 asymptomatic individuals had undergone routine medical check up and had been analysed taking into account various parameters and co-morbidities.
Age wise distribution of co-morbidities and risk factors are as follows
Age group
|
DM
|
Obesity(BMI >25)
|
High Cholesterol
|
Abnormal LDL
|
Low HDL
|
Abnormal Sr.Creatinine
|
<=16 yrs
|
1.5
|
1.5
|
1.2
|
1.2
|
1.5
|
0.9
|
17-25 yrs
|
0.5
|
7.6
|
2.2
|
2.5
|
4.9
|
0.9
|
26-35 yrs
|
4.2
|
15
|
13.9
|
14.9
|
16.9
|
3.9
|
36-45 yrs
|
21.3
|
28.1
|
29.4
|
29.7
|
28.1
|
10.7
|
46-55 yrs
|
35.9
|
28.1
|
30.8
|
30.5
|
27.5
|
22.9
|
56-65 yrs
|
28.2
|
15.6
|
17.6
|
16.7
|
16.9
|
41.3
|
>65 yrs
|
8.4
|
4.1
|
4.9
|
4.5
|
4.3
|
19.5
|
Analysis of the given data and the total prevalence of Fatty changes in the liver are split into the following categories:
1. Fatty liver findings based on Gender ratio (Figure 5)
Ultrasound Finding
|
Male
|
Female
|
Fatty Liver (All Grades)
|
64.5
|
35.5
|
Non fatty liver
|
40
|
60
|
2. Analysis based on severity of fatty liver changes showed an increase in Grade-1 fatty liver changes at about 43.8%. (Figure 9)
Ultrasound Finding
|
Frequency
|
Percent
|
Non fatty liver
|
23587
|
45.7
|
Fatty Liver Grade 1
|
22582
|
43.8
|
Fatty liver Grade 2
|
5124
|
9.9
|
Fatty liver Grade 3
|
319
|
0.6
|
Total
|
51612
|
100.0
|
3. Positive Fatty liver findings in patients with co-morbidities such as Hypertension: 540 individuals (1%), Diabetes mellitus: 10375 (20.1%), Lipids- Cholesterol: 4163(21.4%) LDL: 12426(24.1%) HDL: 15307 ( 29.7%),
BMI: 25408(54%) (Figure 7)
DM
|
Obesity(BMI >25)
|
High Cholesterol
|
Abnormal LDL
|
Low HDL
|
Abnormal Sr.Creatinine
|
20.1
|
49.2
|
26.6
|
24.1
|
29.7
|
3.4
|
Analysis on patients with co-morbidities revealed that fatty liver changes are more prevalent in male patients with diabetes melitus and obesity. Obesity and changes seen in ultrasound co-relates with abnormal creatinine and high cholesterol levels.
Gender
|
DM
|
Obesity(BMI >25)
|
High Cholesterol
|
Abnormal LDL
|
Low HDL
|
Abnormal Sr.Creatinine
|
Male
|
66.9
|
54.6
|
59.2
|
61.2
|
75.6
|
87.2
|
Female
|
33.1
|
45.4
|
40.8
|
38.8
|
24.4
|
12.8
|
Risk factor
|
%
|
Either one of risk factor(DM/HTN/BMI>25/Tot Chol>200/LDL>130/HDL<40/Abnormal Sr.Creatinine)
|
59.9
|
No risk factor
|
41.1
|
(Figure 6)
4. Based on Liver enzymes: AST in 40479 available patients showed 8401(16.3%) elevated values. ALT in 43356 available patients showed 8586 (16.6%).
5. Ultrasound fatty changes(Grade 1+2+3) liver seen in 21415 (54.4%).
Ultrasound investigation revealed that there is evidence of early fatty changes liver constituting to Grade 1 in the severity scale. These changes are seen in 43.8% individuals who attended health check up programme.