Learning objectives
To detect Fatty liver disease in Indian population as a survey in asymptomatic patients presented for health check up programme.
Background
Fatty liver disease is a micro and macro vesicular hepato steatosis due to abnormal retention of lipids within liver cells. Non alcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and metabolic diseases like diabetes, hypertension, obesity, dyslipidemia - are the common causes.1 Less common causes include abetalipoprotienemia, glycogen storage disorder, WC disease, acute fatty liver, lipodystrophy, nutritional, drugs and toxins. Among the various causes for Fatty liver disease, Non alcoholic fatty liver diesease is now one of the common causes for chronic fatty...
Findings and procedure details
Comprehensive analysis of the given data revealed the following findings, The results are classified under various parameters and they revealed that High prevalence of Early fatty liver changes noticed during routine health check up examination of 51612 patients.
A total of 51612 asymptomatic individuals had undergone routine medical check up and had been analysed taking into account various parameters and co-morbidities.
Age wise distribution of co-morbidities and risk factors are as follows
Age group
DM
Obesity(BMI >25)
High Cholesterol
Abnormal LDL
Low HDL
Abnormal Sr.Creatinine...
Conclusion
Ultrasound imaging and Biochemical investigations revealed that there is an increase in the incidence of Early fatty changes in the liver constituting to Grade-1 (43.8%) , Grade-2 fatty liver changes are seen in 9.9% of the population and 0.6% of the individuals had evidence of Grade-3 fatty liver changes.
Ultrasound
Frequency
Percent
Fatty liver (all grades)
28025
54.4
Non fatty liver
23587
45.7
Total
51612
100.0
There issufficient evidence to support and proceed with the next line of investigation and treatment. Further recommended and suggested...
Personal information and conflict of interest
Dr. Ajai RamcharanKattoju; Chennai/IN - Investigator at Apollo Hospitals, Chennai Dr. Sudhakar Kattoju; Chennai/IN - Consultant at Apollo Hospitals, Chennai, Dr. Arshad Akeel- FRCP,FACP Consultant at Apollo Hospitals
References
Mahale AR, Prabhu SD, Nachiappan M, Fernandes M, Ullal S. Clinical relevance of reporting fatty liver on ultrasound in asymptomatic patients during routine health checkups.J Int Med Res. 2018;46(11):4447–4454. doi:10.1177/0300060518793039
Dasarathy S, Dasarathy J, Khiyami A, Joseph R, Lopez R, McCullough AJ. Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study.J Hepatol. 2009;51(6):1061–1067. doi:10.1016/j.jhep.2009.09.001
Pappachan JM, Babu S, Krishnan B, Ravindran NC. Non-alcoholic Fatty Liver Disease: A Clinical Update.J Clin Transl Hepatol. 2017;5(4):384–393. doi:10.14218/JCTH.2017.00013
Perumpail BJ, Khan MA, Yoo ER,...